Eva’s secondment at the Kellett Group in DCU

baseclick GmbH and the Kellett group at DCU have an ongoing research collaboration upon a potential oligonucleotide-based SARS-CoV2 drug, whereas our baseclick ESR Eva Sophie Schönegger, one PostDoc (Dr. Brionna McGroman) and one PhD Student from the Kellett group are working together.

During the secondment in October 2022, Eva learned new techniques and developed new skills. At DCU, Eva was analyzing binding affinities of ligand-clicked oligonucleotides, which she had previously prepared in Munich. Therefore, different approaches were investigated, based on thermal melting, microscale thermophoresis and gel electrophoresis. Moreover, she performed first cleavage assays with the best-performing oligonucleotides