Dr. Thomas Frischmuth

Dr. Thomas Frischmuth

Chief Executive Officer and Chief Scientific Officer

baseclick GmbH


Professional background: Thomas Frischmuth is a Chief Executive Officer (CEO) and Chief Scientific Officer (CSO) at baseclick GmbH, Germany. He has been active in the field of life sciences and medical technology as a researcher, consultant and in leading positions. His research activities range from small-to-large scale chemical and biotechnological synthesis, chemical analysis, molecular and cell biology, diagnostics, medical devices and treatment. He has developed and evaluate six pre-clinical drugs (scientific and TOX), and has taken four of them to phase I / II clinical trials. Currently, one drug is marketed for cancer treatment.

Selected publications:

  • E. S. Schönegger, A. Crisp, M. Radukic, J. Burmester, T. Frischmuth, T. Carell. Orthogonal End Labelling of Oligonucleotides through Dual Incorporation of Click-Reactive NTP Analogues. ChemBioChem, 25, e202300701 (2024). https://doi.org/10.1002/cbic.202300701
  • E. S. Schönegger, A. Crisp, M. Müller, J. Fertl, S. Serdjukow, S. Croce, M. Kollaschinski, T. Carell, T. Frischmuth. Click Chemistry Enables Rapid Amplification of Full-Length Reverse Transcripts for Long-Read Third Generation Sequencing, Bioconjugate Chemistry, 33, 10, 1789-1795 (2022). https://doi.org/10.1021/acs.bioconjchem.2c00353
  • S. Croce, S. Serdjukow, T. Carell, T. Frischmuth. Chemoenzymatic Preparation of Functional Click-Labeled Messenger RNA. ChemBioChem, 21, 11, 1641-1646 (2020). https://doi.org/10.1002/cbic.201900718
  • M. Kollaschinski, J. Sobotta, A. Schalk, T. Frischmuth, B. Graf, S. Serdjukow. Efficient DNA Click Reaction Replaces Enzymatic Ligation, Bioconjugate Chemistry, 31, 3, 507-512 (2020). https://doi.org/10.1021/acs.bioconjchem.9b00805
  • N. Raddaoui, S. Croce, F. Geiger, A. Borodavka, L. Möckl, S. Stazzoni, B. Viverge, C. Bräuchle, T. Frischmuth, H. Engelke, T. Carell. Supersensitive Multifluorophore RNA-FISH for Early Virus Detection and Flow-FISH by Using Click Chemistry, ChemBioChem, 21, 15, 2214-2218 (2020). https://doi.org/10.1002/cbic.202000081